GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12277962 | 1 | rs12277962 | chr11:17655839 | PIK3C2A | chr11:17099277-17229530:- | 0.11 | 3.44 | 0.000604 | Night sleep phenotypes |
| BRCA | cis | rs683250 | 1 | rs1228632 | chr11:83325114 | CCDC90B | chr11:82972506-82997414:- | -0.18 | -4.87 | 1.29E-6 | Subcortical brain region volumes |
| BRCA | cis | rs9783347 | 1 | rs12286683 | chr11:18348662 | GTF2H1 | chr11:18343816-18388590:+ | 0.3 | 7.75 | 2.09E-14 | Pancreatic cancer |
| BRCA | cis | rs1568889 | 1 | rs12287732 | chr11:28120845 | METT5D1 | chr11:28129798-28355054:+ | -0.11 | -3.37 | 0.000773 | Bipolar disorder |
| BRCA | cis | rs12295403 | 1 | rs12295403 | chr11:18689653 | LDHC | chr11:18433853-18472792:+ | -0.2 | -4.6 | 4.77E-6 | Ovarian reserve |
| BRCA | cis | rs11174436 | 1 | rs12297480 | chr12:62795587 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.75 | 0.000185 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs1789924 | 1 | rs1229854 | chr4:100282550 | ADH1C | chr4:100257651-100273917:- | -0.21 | -6.72 | 3.03E-11 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs1789924 | 1 | rs1229978 | chr4:100256199 | ADH1C | chr4:100257651-100273917:- | -0.2 | -6.32 | 3.91E-10 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs1789924 | 1 | rs1229978 | chr4:100256199 | ADH4 | chr4:100044835-100065449:- | -0.11 | -3.38 | 0.000762 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs12309274 | 1 | rs12301299 | chr12:991710 | RAD52 | chr12:1021255-1099219:- | -0.3 | -6.57 | 7.97E-11 | Colorectal cancer |
| BRCA | cis | rs12303914 | 1 | rs12303914 | chr12:10471050 | KLRD1 | chr12:10457050-10469849:+ | -0.12 | -4.55 | 6.11E-6 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BRCA | cis | rs11174436 | 1 | rs12310651 | chr12:62730305 | FAM19A2 | chr12:62102043-62653925:- | 0.18 | 3.87 | 0.000115 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs12311259 | chr12:62739008 | FAM19A2 | chr12:62102043-62653925:- | 0.18 | 3.95 | 8.25E-5 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs12311279 | chr12:62695332 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.65 | 0.00027 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs12309274 | 1 | rs12312603 | chr12:988269 | RAD52 | chr12:1021255-1099219:- | -0.33 | -7.45 | 1.9E-13 | Colorectal cancer |